The neighborhood is named after George H. Pendleton (1825–1889), a U.S. Representative and Senator whose house still stands in the area.

Pendleton is a small neighborhood in Cincinnati, Ohio, located on the east side of Over-the-Rhine, north of the Central Business District, and south of Mount Auburn.

The triangular-shaped and relatively small neighborhood stands on its own (since splitting from OTR in 1987) as one of Cincinnati’s 52 neighborhoods, bordered by the busy roadways of Reading, Liberty and Sycamore.

It is home to the Pendleton Art Center or PAC and is often referred to as “The Pendleton Art District.”

The Pendleton Art Center was founded in 1991 by the late Jim Verdin, a longtime champion of Pendleton. It has since grown to house one of the world’s largest collection of artists under one roof.

Verdin’s other influences in the neighborhood include the Pendleton Square Complex and the development of the “old car barn,” now Nicola’s Ristorante.